Spurs saw off North London rivals Arsenal in the quarter-final, while the Blues defeated Bournemouth 1-0.
Mauricio Pochettino’s men have already beaten Chelsea 3-0 in the Premier League this season.
The other semi-final will take place on Wednesday, between Manchester City and Burton Albion.
Kick off is 9pm West African time.
Tottenham XI vs Chelsea: Gazzaniga, Trippier, Alderweireld, Sanchez, Rose, Winks, Sissoko, Eriksen, Dele, Son, Kane
Chelsea XI vs Spurs: Kepa, Azpilicueta, Christensen, Rudiger, Alonso, Jorginho, Kante, Barkley, Willian, Hazard, Hudson-Odoi
Tuesday, January 8
21:00 Tottenham Hotspur vs Chelsea
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Originally Authored By: Ifreke Inyang